منابع مشابه
Gene dosage balance in cellular pathways: implications for dominance and gene duplicability.
THE gene dosage balance hypothesis (GDBH) profrom the selective cost of their overproduction. Thus, poses, in a narrow sense, that stoichiometric imbalsome genes encoding interacting pairs should remain ances in macromolecular complexes can be a source of as single copies (case of B) or otherwise undergo codominant phenotypes. Gene dosage balance in such duplication with genes encoding their pa...
متن کاملEvolutionary constraints imposed by gene dosage balance.
The gene dosage balance hypothesis states that a concentration imbalance among components of macromolecules is often deleterious. Thus this notion potentially provides a mechanistic explanation for understanding genetic dominance and gene duplicability. Accumulating evidence emerged from recent genomic data has strongly supported this hypothesis. Further efforts are needed to understand dosage ...
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Objective(s): The aim of this study was to investigate the effect of vitamin D on glucose metabolism, as well as the expression of five key genes involved in the development of diabetes complications in liver tissue of diabetic rats. Materials and Methods: Twenty-four male Sprague–Dawley rats were randomly divided into three groups (8 ra...
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This article has no abstract.
متن کاملDetermination of aspartic protease gene dosage in the Onchocerca volvulusgenome
Aspartic proteases are a relatively small group of enzymes which express in various nematodes including Onchocerca volvulus. An estimation of the gene copy number corresponding to the OV7A clone, which contains a cDNA insert encoding approximately two-thirds of the entire coding sequence of aspartic protease of O. volvulus, was made by slot blot analysis in a closely related species O. gibsonig...
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ژورنال
عنوان ژورنال: Genetics
سال: 2004
ISSN: 1943-2631
DOI: 10.1534/genetics.104.029785